Chen Jie Ying Blm (2024)

1. USP37 regulates DNA damage response through stabilizing and ...

  • The human RecQ helicase BLM is involved in the DNA damage response, DNA metabolism, and genetic stability. Loss of function mutations in BLM cause the genetic ...

  • Abstract. The human RecQ helicase BLM is involved in the DNA damage response, DNA metabolism, and genetic stability. Loss of function mutations in BLM caus

2. USP37 regulates DNA damage response through stabilizing and ...

  • The human RecQ helicase BLM is involved in the DNA damage response, DNA metabolism, and genetic stability. Loss of function mutations in BLM cause the genetic ...

  • The human RecQ helicase BLM is involved in the DNA damage response, DNA metabolism, and genetic stability. Loss of function mutations in BLM cause the genetic instability/cancer predisposition syndrome Bloom syndrome. However, the molecular mechanism underlying the regulation of BLM in cancers remains largely elusive. Here, we demonstrate that the deubiquitinating enzyme USP37 interacts with BLM and that USP37 deubiquitinates and stabilizes BLM, thereby sustaining the DNA damage response (DDR). Mechanistically, DNA double-strand breaks (DSB) promotes ATM phosphorylation of USP37 and enhances the binding between USP37 and BLM. Moreover, knockdown of USP37 increases BLM polyubiquitination, accelerates its proteolysis, and impairs its function in DNA damage response. This leads to enhanced DNA damage and sensitizes breast cancer cells to DNA-damaging agents in both cell culture and in vivo mouse models. Collectively, our results establish a novel molecular mechanism for the USP37-BLM axis in regulating DSB repair with an important role in chemotherapy and radiotherapy response in human cancers.

3. Bleomycin (BLM) Induces Epithelial-to-Mesenchymal ...

  • In this study, we aimed to determine whether bleomycin (BLM), an agent that causes pulmonary fibrosis, induces the EMT of the alveolar epithelial cell line A ...

  • PDF

4. Dexamethasone and lactoferrin induced PMN-MDSCs relieved ...

  • 26 feb 2021 · Our study shows that DXM/lactoferrin PMN-MDSCs are a promising cell therapy for inflammatory adverse events of anti-cancer therapies.

  • In this era of immune checkpoint inhibitors, inflammatory adverse events of anti-cancer therapies continue to pose a major challenge. Glucocorticoids, as the mainstay, were limited by serious side effects. Glucocorticoids induce myeloid-derived suppressor cells (MDSCs), and lactoferrin-induced polymorphonuclear MDSCs (PMN-MDSCs) were shown to relieve inflammatory conditions. Combined treatment with dexamethasone (DXM) and lactoferrin increased the generation of PMN-MDSCs in vitro (DXM/lactoferrin PMN-MDSCs) compared to DXM or lactoferrin treatment alone. DXM/lactoferrin PMN-MDSCs were distinct from tumor PMN-MDSCs in vivo with regard to gene expression profiles. DXM upregulated the myeloid cell response to lactoferrin by inducing the lactoferrin receptor Lrp1. DXM/lactoferrin PMN-MDSCs presented anti-bacterial capability, increased PGE2 production, increased survival capability, and decreased tumor tissue homing. Transfer of DXM/lactoferrin PMN-MDSCs relieved cisplatin-induced acute kidney failure, bleomycin-induced interstitial pneumonia, and allergic pneumonitis effectively without promoting tumor development. Our study shows that DXM/lactoferrin PMN-MDSCs are a promising cell therapy for inflammatory adverse events of anti-cancer therapies. Li et al. show that dexamethasone and lactoferrin induced polymorphonuclear myeloid-derived suppressor cells relieve inflammatory conditions in mouse models with minimal effect on tumour growth. This work demonstrates pro...

5. Iguratimod as an alternative therapy for systemic sclerosis and ... - Frontiers

  • This study aimed to assess the effectiveness of iguratimod (IGU) as an alternative treatment for systemic sclerosis (SSc), especially in the prevention of ...

  • ObjectivesThis study aimed to assess the effectiveness of iguratimod (IGU) as an alternative treatment for systemic sclerosis (SSc), especially in the preven...

6. The Journal of Practical Medicine 2004 Issue 8 ddp+5-fu+blm hua ...

  • The Journal of Practical Medicine ddp+5-fu+blm hua liao fang an yong yu she ai de shu qian you dao hua liao 2004 Issue 1006-5725.

  • The Journal of Practical Medicine ddp+5-fu+blm hua liao fang an yong yu she ai de shu qian you dao hua liao 2004 Issue 1006-5725

7. Thermodynamics and kinetics of the cleavage of DNA catalyzed by ...

  • Microcalorimetry and UV‐vis spectroscopy were used to conduct thermodynamic and kinetic investigations of the scission of calf thymus DNA catalyzed by bleomycin ...

  • Microcalorimetry and UV‐vis spectroscopy were used to conduct thermodynamic and kinetic investigations of the scission of calf thymus DNA catalyzed by bleomycin A5 (BLM‐A5) in the presence of ferrous ion and oxygen. The molar reaction enthalpy for the cleavage, the Michaelis–Menten constant for calf thymus DNA and the turnover number of BLM‐A5 were calculated by a novel thermokinetic method for an enzyme‐catalyzed reaction to be −577 ± 19 kJ·mo…

8. 农业生物技术学报

  • Screening of Human BLM Gene-related LncRNAs and Analysis of Its Expression in Different Prostate Cancer Cells ... Jie, CHEN Ying-Lian, XU Hou-Qiang. 2020 Vol.28 ( ...

9. International Journal of Clinical and Experimental Medicine--Open ...

  • An open access journal for medicine.

10. Asper School of Business | Diversity Research Awarded - UM Today

  • Get to Know Asper School of Business Director of EDI, Jieying Chen. Associate professor of business administration and newly appointed director of EDI ...

  • Asper Assistant Professor in Finance, Dr. Shiu-Yik (Yik) Au, and his co-investigator, Andréanne Tremblay from Université Laval have been awarded a prestigious Social Services and Humanities Council

11. Inhibition of EP300 and DDR1 synergistically alleviates pulmonary ...

  • Chen, Bleomycin (BLM) Induces Epithelial-to ... Chen, Identification of novel inhibitors of DDR1 ... Chen, Yongta Wang, Ailin Tao, Yanhua Du, Jie Yan.

  • https://doi.org/10.1016/j.biopha.2018.07.132 ·

12. Unraveling the mechanism of ethyl acetate extract from Prismatomeris ...

  • Monocyte-derived AMs play a critical role in bleomycin (BLM)-induced pulmonary fibrosis, and their differentiation into AMs remains unaffected by ...

  • IntroductionPulmonary fibrosis is a terminal lung disease characterized by fibroblast proliferation, extracellular matrix accumulation, inflammatory damage, ...

13. NYUHSL Faculty Bibliography - NYU Health Sciences Library

  • Whether BLM heterozygous germline mutations (BLM+/-) cause human cancer remains unclear. We sequenced the germline DNA of 155 mesothelioma patients (33 familial ...

  • Searched for:

14. Findings - EMNLP 2023

  • Blackbird language matrices (BLM), a new task for rule-like generalization in neural networks: Can Large Language Models pass the test? Paola Merlo. DistillCSE: ...

  • The Accepted Findings of EMNLP 2023

15. 单 江娟 - Open Access Library - OALib

  • 单 江娟. 个人信息不予以公开. Information Technologies Marketing Statistics and Econometrics Development Economics Political Economy. 已审文章.

  • ...

Chen Jie Ying Blm (2024)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Stevie Stamm

Last Updated:

Views: 6395

Rating: 5 / 5 (80 voted)

Reviews: 87% of readers found this page helpful

Author information

Name: Stevie Stamm

Birthday: 1996-06-22

Address: Apt. 419 4200 Sipes Estate, East Delmerview, WY 05617

Phone: +342332224300

Job: Future Advertising Analyst

Hobby: Leather crafting, Puzzles, Leather crafting, scrapbook, Urban exploration, Cabaret, Skateboarding

Introduction: My name is Stevie Stamm, I am a colorful, sparkling, splendid, vast, open, hilarious, tender person who loves writing and wants to share my knowledge and understanding with you.